Below: aliphatic region of the 2D CC spectrum of 15N, 13C labeled alpha-synuclein protein monomer seeded from a brain tissue sample (250 ms CORD mixing), acquired at 900 MHz (1H field) at the National Magnetic Resonance Facility at Madison (NMRFAM, @NMRFAM) , utilizing a PhoenixNMR HFXY probe fitted with a 1.6mm module and PhoenixNMR speed controller.
The PhoenixNMR HFXY probe was operated in double resonance mode at MASS = 20 kHz; mixing time = 250 ms; total time to acquire spectrum = 20 hrs using 4 blocks of 1024 rows each; 8 acquisitions per row; pulse delay = 1.5 s; CORDxy4 recoupling plus SPINAL decoupling.
Data courtesy Prof. Chad M. Rienstra, Dr. Marco Tonelli and Dr. Dwaipayan Mukhopadhyay. Data were acquired at the National Magnetic Resonance Facility at Madison ( NMRFAM, @NMRFAM). This 900 MHz SSNMR instrument and probe are available for use at NMRFAM by any scientist worldwide.
Dynamic Nuclear Polarization (DNP) signal-enhancement capability is now available in combination with innovative Phoenix Solid-State NMR (SSNMR) probe technology to expand the scope and sensitivity of biomolecular and materials SSNMR research at 400-600 MHz. The new Phoenix MAS-DNP probe system utilizes the same robust, professional design strategy that scientists have come to expect in all Phoenix SSNMR probes and accessories.
Overview of the Phoenix DNP Innovation
Add a new Phoenix DNP probe to expand capability on an existing DNP SSNMR instrument; or
Add a Turn-key DNP System, including gyrotron, to an existing 9.4 – 14.1 T, Wide-Bore SSNMR instrument, pairing the robust Phoenix NMR probe technology with Bridge12 Technologies components to complete the DNP package;
Combine DNP with HFXY and HFX probe configurations;
PhoenixNMR LLC is very pleased to announce an agreement with Bruker Biospin for the supply of PhoenixNMR probes on new and upgrade Bruker systems. Under the terms of the agreement, which is effective worldwide, Bruker will offer PhoenixNMR probes to supplement their solid state probe product line. PhoenixNMR will provide installation and warranty service on its probes.
The unique capabilities of PhoenixNMR to provide full broadband triple resonance probes, with the ability to tune to < 15MHz, and to add simultaneous H&F capability, all in a standard bore format is a powerful matchup with the capabilities of the Bruker Biospin console and magnet systems. Take your science to new heights tomorrow by starting a conversation today. Give your local Bruker salesperson a call and see what they can do for you.
Commenting on the agreement, Dr. John Heinrich, the CEO of PhoenixNMR stated:
“We are very pleased to have the opportunity to supply solid state NMR probes to Bruker. Our ability to provide advanced probe performance in standard bore magnet systems will provide significant new research capabilities to Bruker customers.”
Dr. Werner Maas, President of the Bruker BioSpin MRS division, added:
“We are excited to be able to support the NMR community with the expanded solid state NMR probe offerings from PhoenixNMR. The combination of these advanced probes with the Avance III HD or the new Avance NEO systems will lead to the ultimate performance and flexibility in solid state NMR and support our drive to broaden the use of solid state NMR in structural biology and material science.”
Are you interested in doing routine solids NMR but don’t need all the performance that comes with the Phoenix HXY Premium?
Introducing the Phoenix HX probe available in rotor sizes from 1.6mm up to 6mm for 300MHz-700MHz! This affordable probe, which is about half the cost of the fully featured HXY probe, makes it easy to add solids to any existing standard bore liquids NMR system by bundling with a speed controller from PhoenixNMR. Click here for more information
PhoenixNMR is offering sample kits in 1.6, 3.2, and 4mm narrow bore rotor sizes. These sample kits work with all PhoenixNMR probes as well as Varian/Agilent narrow bore probes. Calibrate pulse widths, set magic angle, measure sensitivity, and check lineshape. They are a great way to validate your system and can be used in troubleshooting whether there is a system issue, a problem with a sample, or the probe. If your probe has a deuterium lock channel, we have a D2O rotor utilizing our BioSolids sample spacers. An additional rotor is available to initially shim on Proton that aids in final lineshape on 13C. Looking for a different size than what is listed? Ask us, and we can discuss your needs. Click here for more information
Thank you to those who stopped by to see us at ENC in Pittsburgh. We enjoyed hearing from all of you about the science that you are exploring and talking with you about how our products can help you achieve it. Take a look below at our newest offerings and click here for a quote or more information.